Factors impacting participation in research during the COVID-19 pandemic: results from a survey of patients in the ophthalmology outpatient department.

BACKGROUND: Understanding public and patient attitudes to clinical research is paramount to successful recruitment. The COVID-19 pandemic has led to additional hurdles in achieving this. Our aim is to understand the current factors and attitudes towards clinical trial participation in order to assist in recruitment to clinical trials. METHODS: We conducted face-to-face interviews with patients in the outpatient department at a tertiary eye hospital facilitated by a 32-item questionnaire developed by the research team. Patient characteristics were correlated with their responses, in addition to qualitative thematic text analysis. RESULTS: A total of 53 patients were interviewed. Forty per cent indicated that they would be willing to participate in clinical research in the current climate. General motivating factors for involvement in research included personal gain, altruism and contribution to innovation. Factors limiting participation included concerns regarding own safety, inconvenience, accessibility and lack of benefit. 22.6% of participants felt that the COVID-19 pandemic has changed their outlook on research. These were categorised into positive (increased awareness of the importance and need for research, altruism) and negative (increased anxiety, need to minimise exposure to the hospital environment) influences. CONCLUSIONS: Factors influencing patients' decisions to participate in trials are similar to those observed prior to COVID-19 but with an increased focus on the environment the research is conducted in. The COVID-19 pandemic has had positive and negative impacts on patient attitudes towards research. Trial design, with a particular focus on setting and safety measures, in reassuring patients is increasingly important.

The iVAN Project: an innovative solution to meet the challenges in trial recruitment during a global pandemic

PurposeCOVID‐19 has greatly affected the number of patients willing and able to attend hospital, with research activity also greatly impacted. Imperial College Ophthalmology Research Group (ICORG) have observed clinical backlogs and a 77% decrease in trial patient recruitment. As a first of its kind, this project aims to combat clinic waiting lists and patient confidence in trial involvement through creating a safe, flexible and decentralised healthcare environment with iVAN, a mobile research unit.MethodsA survey of outpatients was performed exploring attitudes towards visiting hospital for clinical and research reasons amidst a pandemic. A vehicle was equipped with state‐of‐the‐art clinical research facilities in a COVID‐safe environment. A multi‐stage approach was taken in order to achieve relevant driving and roadworthiness certification, multi‐disciplinary involvement and healthcare network planning in order to ensure the smooth progression of the project. A pilot period of clinical visits was carried out and evaluated in close vicinity to the hospital.ResultsOf the 53 patients surveyed, 60% percent of patients were not willing to take part in clinical trials with others having concerns related to travel and being in the hospital. The final layout of the vehicle includes imaging devices, a visual field analyser, IT equipment and space for staff to see patients. Social distancing and infection control have been ensured to provide a pleasant and safe working environment. A pilot period is underway assessing staff and patient satisfaction along with capacity and trial data runs, with future plans involving satellite clinics in the community.ConclusionsFlexible and innovative service provision continues to be required to minimise morbidity attributable to the pandemic. The iVan has the facilities to bring decentralised, specialist ophthalmic care into local communities in a COVID‐safe manner, whilst being a useful tool to engage future research participants.